Ruqaiyah Pengarang Fatmawati Amir Pengarang Ayatullah Harun Pengarang Nusratuddin Abdullah Pengarang Nasruddin A Mappeware Pengarang Alfina Baharuddin Pengarang Mochammad Hatta Pengarang

FKBP5 protein plays an important role in determining sensitivity to negative glucocorticoid feedback, a key mechanism for stopping the HPA axis response in stressful episodes. Methods: The design of this study is a quasi-experimental approach / quasi experimental and one group design pre and post test design with group control. The sample in this study amounted to each group of 12 respondents as control and treatment of yoga. Results: There was a significant difference (p = 0.000 <∝) on average FKBP5 gene expression in the control group before (7.1 ± 0.59) and after observation (9.43 ± 0.68), meaning that there was an increase in cortisol levels in the control group in the control group before and after observation, while the treatment group showed a significant difference (p = 0.001 <∝), the average expression of FKBP5 gene before being treated (7.52 ± 0.49) and after being treated (6.88 ± 0.54), Conclusion: There was a significant difference (p = 0.000 <∝) on average FKBP5 gene expression in the control group, which means that prenatal yoga decreased FKBP5 gene expression before and after treatment. Keywords: MRNA expression, FKBP5 gene, Yoga, Trimester III