Ruqaiyah Pengarang Abdullah, Nusratuddin Pengarang Hatta, Mochammad Pengarang Arifuddin, Syarfianty Pengarang Syamsuddin, Saidah Pengarang Idris, Irfan Pengarang Bukhari,Agusalim Pengarang

Abstract Background: Stress triggers the release of corticotrophic release factor (CRF) from the hypothalamus which in turn stimulates the anterior pituitary to release adrenocorticotrophic hormone (ACTH). Methods: The design of this study is a quasi-experimental approach / quasi experimental and one group design pre and post test design with group control. The sample in this study amounted to 24 respondents Results: Based on the results of the study showed that the sample LA24 (7,935) was the highest sample fold fold change and the lowest in the sample LA15 (6,194). Whereas in the post test results it was found that the LB18 sample (10,580) was the highest sample in fold change and the lowest was in the LB15 sample (8,472). Conclusion: There is a significant relationship / correlation between CRHR1 levels and FKBP5 levels (p = 0.001 <∝). This is indicated by the high / strong correlation coefficient value which is 0.846. A positive value at 0.846 indicates that there is a positive relationship or a concomitant relationship, namely the influence of yoga exercises will result in a decrease in CRHR1 levels and will further reduce the effect of FKBP5 levels in third trimester pregnant women. Keywords: prenatal yoga, CRHR1 gene, FKBP5 gene , real time-PCR